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磷酸化離子型谷氨酸受體1抗體

產品貨號：

BN40895R
中文名稱：

磷酸化離子型谷氨酸受體1抗體
英文名稱：

Rabbit anti-Phospho-NMDAR1 (Ser896) Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN40895R-100ul

100ul

￥2470.00

交叉反應：Human,Mouse(predicted:Rat,Chicken,Dog,Cow) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱	Phospho-NMDAR1 (Ser896)
中文名稱	磷酸化離子型谷氨酸受體1抗體
別名	NMDAR1 C1 (phospho S896); p-NMDAR1 C1 (phospho S896); NMDAR1(Phospho-Ser896); NMDAR1(Phospho-S896); NMDAR1 C1 (phospho S896); p-NMDAR1(S896); p-NMDAR1(Ser896); NMDA-NR1; N-Methyl-d-Asprtate receptor 1; GRIN1; NMDA1; NR1; Glutamate [NMDA] receptor subunit zeta 1; Glutamate receptor ionotropic N methyl D aspartate 1; Grin 1; Grin1; N methyl D aspartate receptor channel; N-methyl-D-aspartate receptor; N-methyl-D-aspartate receptor subunit NR1; NMD-R1; NMDA 1; NMDA NR1; NMDA R1; NMDA receptor 1; NMDA1; NMDAR 1; NMDAR; NR 1; NMDZ1_HUMAN.
產品類型	磷酸化抗體
研究領域	細胞生物免疫學神經生物學信號轉導轉錄調節因子激酶和磷酸酶細胞類型標志物
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Mouse, (predicted: Human, Rat, Chicken, Dog, Cow, )
產品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	103kDa
細胞定位	細胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated Synthesised phosphopeptide derived from human NMDAR1 around the phosphorylation site of Ser896:RR(p-S)SK <Cytoplasmic>
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008] Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Subunit: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ. Interacts with LRFN1 and LRFN2. Interacts with MYZAP. Subcellular Location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Post-translational modifications: NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity. DISEASE: Defects in GRIN1 are the cause of mental retardation autosomal dominant type 8 (MRD8) [MIM:614254]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily. SWISS: Q05586 Gene ID: 2902 Database links: Entrez Gene: 2902 Human Entrez Gene: 14810 Mouse Entrez Gene: 24408 Rat Omim: 138249 Human SwissProt: Q05586 Human SwissProt: P35438 Mouse SwissProt: P35439 Rat Unigene: 558334 Human Unigene: 278672 Mouse Unigene: 9840 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神經細胞標志物 (NMDAR1)N-甲基-D-天門冬氨酸受體(NMDAR)是興奮性氨基酸受體亞型之一，是由NMDAR1與不同的NMDAR2亞基組成的異聚體。 NMDAR1又稱GluR1 (Glutamate Receptor 1)近年實驗研究發現，許多NMDAR拮抗藥均具有鎮痛活性，表明NMDAR在痛覺傳遞中具有重要作用，這為新型鎮痛藥的研究開發提供了新的作用靶點。