最近搜索:細胞培養 微生物學 分子生物 生物化學
    首頁>>免疫學>>一抗>>磷酸化組蛋白去乙酰化酶7抗體
    磷酸化組蛋白去乙酰化酶7抗體
    • 產品貨號:
      BN40882R
    • 中文名稱:
      磷酸化組蛋白去乙酰化酶7抗體
    • 英文名稱:
      Rabbit anti-phospho-HDAC7 (Ser358) Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN40882R-100ul

      100ul

      ¥2470.00

      交叉反應:Mouse,Rat(predicted:Human) 推薦應用:IHC-P,IHC-F,IF,ELISA

    產品描述

    英文名稱phospho-HDAC7 (Ser358)
    中文名稱磷酸化組蛋白去乙酰化酶7抗體
    別    名HDAC7 (phospho S358); HDAC7 (phospho Ser358); p-HDAC7 (Ser358); HD 7a; HD7a; HDAC 7; HDAC 7A; HDAC7; HDAC7A; Histone deacetylase 7; Histone deacetylase 7A; DKFZP586J0917; OTTHUMP00000202813; OTTHUMP00000202814; FLJ99588; HDAC7_HUMAN.  
    產品類型磷酸化抗體 
    研究領域腫瘤  免疫學  信號轉導  細胞凋亡  轉錄調節因子  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Mouse, Rat,  (predicted: Human, )
    產品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量31kDa
    細胞定位細胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated Synthesised phosphopeptide derived from human HDAC7 around the phosphorylation site of Ser358:TR(p-S)EP 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

    Function:
    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene.

    Subunit:
    Interacts with HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, NCOR1, NCOR2, SIN3A, SIN3B, RBBP4, RBBP7, MTA1L1, SAP30 and MBD3. Interacts with the 14-3-3 protein YWHAE, MEF2A, MEF2B and MEF2C. Interacts with KAT5 and EDNRA. Interacts with KDM5B. Interacts with ZMYND15. Interacts with PML (isoform PML-4).

    Subcellular Location:
    Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.

    Post-translational modifications:
    May be phosphorylated by CaMK1. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylation at Ser-155 by MARK2, MARK3 and PRKD1 promotes interaction with 14-3-3 proteins and export from the nucleus. Phosphorylation at Ser-155 is a prerequisite for phosphorylation at Ser-181.

    Similarity:
    Belongs to the histone deacetylase family. HD type 2 subfamily.

    SWISS:
    Q8WUI4

    Gene ID:
    51564

    Database links:

    Entrez Gene: 51564 Human

    Entrez Gene: 56233 Mouse

    Entrez Gene: 84582 Rat

    Omim: 606542 Human

    SwissProt: Q8WUI4 Human

    SwissProt: Q8C2B3 Mouse

    SwissProt: Q99P96 Rat

    Unigene: 200063 Human

    Unigene: 384027 Mouse

    Unigene: 203327 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.





















    image.png

    亚洲综合中文字幕无线码| 亚洲色成人四虎在线观看| 少妇中文字幕乱码亚洲影视| 亚洲av无码成人精品区| 亚洲国产综合精品| 亚洲国产人成在线观看| 亚洲色av性色在线观无码| 亚洲午夜久久影院| 亚洲第一极品精品无码久久| 亚洲AV成人片色在线观看| 中文字幕亚洲不卡在线亚瑟| 亚洲国产精品狼友中文久久久| WWW亚洲色大成网络.COM| 国产亚洲欧美在线观看| 深夜国产福利99亚洲视频| 亚洲国产91精品无码专区| 亚洲av无码天堂一区二区三区 | 久久精品亚洲综合| 亚洲成色在线影院| 亚洲精品综合久久中文字幕| 亚洲国产品综合人成综合网站| 亚洲av乱码一区二区三区| 亚洲另类古典武侠| jiz zz在亚洲| 在线观看亚洲视频| 亚洲伊人久久综合影院| 国产亚洲3p无码一区二区| 久久精品亚洲一区二区| 91精品国产亚洲爽啪在线影院| 亚洲国产视频网站| 亚洲日韩精品无码AV海量| 精品亚洲视频在线| 国产亚洲自拍一区| 亚洲AV永久无码区成人网站| 91久久亚洲国产成人精品性色 | 亚洲精品成人在线| 亚洲精品午夜无码专区| 99人中文字幕亚洲区| 亚洲午夜一区二区三区| 香蕉视频亚洲一级| 亚洲色大成网站WWW久久九九|