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    磷酸化活化復制因子2抗體
    • 產品貨號:
      BN40851R
    • 中文名稱:
      磷酸化活化復制因子2抗體
    • 英文名稱:
      Rabbit anti-phospho-ATF2 (Thr69/71) Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

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    • BN40851R-100ul

      100ul

      ¥2470.00

      交叉反應:Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit) 推薦應用:IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    產品描述

    英文名稱phospho-ATF2 (Thr69/71)
    中文名稱磷酸化活化復制因子2抗體
    別    名ATF2 (phospho T69 + T71); ATF2 (phospho Thr69 + Thr71); p-ATF2 (T69 + T71); p-ATF2 (Thr69 + Thr71); CREB 2; HB 16;Activating Transcription Factor 2; ATF 2; Atf-2; ATF2 protein; cAMP Response Element Binding Protein 2; cAMP response element binding protein CRE BP1; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; CRE BP1; CRE-BP; CREB 2; CREB2; CREBP1; Cyclic AMP dependent transcription factor ATF 2; Cyclic AMP-responsive; ATF2_HUMAN.  
    產品類型磷酸化抗體 
    研究領域免疫學  染色質和核信號  轉錄調節因子  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Horse, Rabbit, )
    產品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2ug/Test IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量45kDa
    細胞定位細胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated Synthesised phosphopeptide derived from human ATF2 around the phosphorylation site of Thr69/71:DQ(p-T)P(p-T)PT 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹ATF2 is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes. Many of these genes are important in cell growth and differentiation, and in stress and immune responses. ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families. It is a stronger activator as a heterodimer with cJun than as a homodimer. Several isoforms of ATF2 arise by differential splicing. The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain. Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, seemingly in a protein phosphatase-dependent mechanism. Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, inflammatory cytokines, and UV irradiation. This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase. ATF2 is abundantly expressed in brain.

    Subunit:
    Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Interacts with SMAD3 and SMAD4. Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity.

    Subcellular Location:
    Nucleus.

    Tissue Specificity:
    Abundant expression seen in the brain.

    Post-translational modifications:
    Phosphorylation of Thr-69 by MAPK14 and MAPK11, and at Thr-71 by MAPK1/ERK2, MAPK3/ERK1, MAPK11, MAPK12 and MAPK14 in response to external stimulus like insulin causes increased transcriptional activity. Phosphorylated by PLK3 following hyperosmotic stress. Also phosphorylated and activated by JNK and CaMK4.

    Similarity:
    Belongs to the bZIP family. ATF subfamily.
    Contains 1 bZIP domain.
    Contains 1 C2H2-type zinc finger.

    SWISS:
    P15336

    Gene ID:
    1386

    Database links:

    Entrez Gene: 1386 Human

    Entrez Gene: 100047997 Mouse

    Entrez Gene: 11909 Mouse

    Entrez Gene: 81647 Rat

    Omim: 123811 Human

    SwissProt: P15336 Human

    SwissProt: P16951 Mouse

    SwissProt: Q00969 Rat

    Unigene: 592510 Human

    Unigene: 209903 Mouse

    Unigene: 9825 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    轉錄調節因子(Transcriptin Regulators)


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