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環(huán)指蛋白105抗體

產(chǎn)品貨號：

BN40695R
中文名稱：

環(huán)指蛋白105抗體
英文名稱：

Rabbit anti-RNF105 Polyclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規(guī)格

售價

備注
BN40695R-100ul

100ul

￥2360.00

交叉反應(yīng)：Mouse,Rat(predicted:Human) 推薦應(yīng)用：IHC-P
BN40695R-200ul

200ul

￥3490.00

交叉反應(yīng)：Mouse,Rat(predicted:Human) 推薦應(yīng)用：IHC-P

產(chǎn)品描述

英文名稱	RNF105
中文名稱	環(huán)指蛋白105抗體
別名	DCRR1; E3 ubiquitin protein ligase TTC3; E3 ubiquitin-protein ligase TTC3; Protein DCRR1; RING finger protein 105;Tetratricopeptide repeat protein 3 (TPR repeat protein D); Tetratricopeptide repeat protein 3; TPR repeat protein 3; TPR repeat protein D; TPRD; TPRDI; TPRDII; TPRDIII; TTC3; TTC3_HUMAN.
研究領(lǐng)域	細胞生物神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) G蛋白信號
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應(yīng)	Mouse, Rat, (predicted: Human, )
產(chǎn)品應(yīng)用	IHC-P=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	230kDa
細胞定位	細胞核
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human RNF105:251-350/2025
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT. Function: E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT. Subunit: Interacts (when phosphorylated on Ser-378) with AKT1, AKT2 and AKT3 (when phosphorylated). Interacts with CIT. Subcellular Location: Nucleus. Tissue Specificity: Found in all tissues examined. Post-translational modifications: Phosphorylation on Ser-378 by Akt is required for ubiquitin ligase activity. Similarity: Contains 1 RING-type zinc finger. Contains 4 TPR repeats. SWISS: P53804 Gene ID: 7267 Database links: Entrez Gene: 7267 Human Omim: 602259 Human SwissProt: P53804 Human Unigene: 368214 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.