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    首頁>>免疫學>>一抗>>酪氨酸蛋白磷酸酶非受體型12抗體
    酪氨酸蛋白磷酸酶非受體型12抗體
    • 產品貨號:
      BN40568R
    • 中文名稱:
      酪氨酸蛋白磷酸酶非受體型12抗體
    • 英文名稱:
      Rabbit anti-PTPN12 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN40568R-100ul

      100ul

      ¥2360.00

      交叉反應:Human(predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應用:WB,ELISA

    • BN40568R-200ul

      200ul

      ¥3490.00

      交叉反應:Human(predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應用:WB,ELISA

    產品描述

    英文名稱PTPN12
    中文名稱酪氨酸蛋白磷酸酶非受體型12抗體
    別    名Protein tyrosine phosphatase G1; Protein tyrosine phosphatase non receptor type 12; Protein-tyrosine phosphatase G1; PTN12_HUMAN; PTP PEST; PTP-PEST; PTPG1; Ptpn12; Tyrosine protein phosphatase non receptor type 12; Tyrosine-protein phosphatase non-receptor type 12.  
    研究領域腫瘤  細胞生物  信號轉導  細胞周期蛋白  激酶和磷酸酶  細胞分化  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量88kDa
    細胞定位細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human PTPN12:1-100/780 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

    Function:
    Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2.

    Subunit:
    Interacts with TGFB1I1 (By similarity). Interacts with PSTPIP1. Interacts with PTK2B/PYK2. Interacts with LPXN (By similarity). {ECO:0000250}.

    Subcellular Location:
    Cytoplasm.

    Post-translational modifications:
    Phosphorylated by STK24/MST3 and this results in inhibition of its activity. {ECO:0000269|PubMed:17046825}.

    Similarity:
    Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. Contains 1 tyrosine-protein phosphatase domain.

    SWISS:
    Q05209

    Gene ID:
    5782

    Database links:

    Entrez Gene: 5782 Human

    Entrez Gene: 531877 Cow

    Entrez Gene: 19248 Mouse

    Entrez Gene: 117255 Rat

    Omim: 600079 Human

    SwissProt: Q05209 Human

    SwissProt: P35831 Mouse

    SwissProt: Q63745 Rat

    Unigene: 34723 Cow

    Unigene: 61812 Human

    Unigene: 319117 Mouse

    Unigene: 10707 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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