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    RNA結(jié)合蛋白56抗體
    • 產(chǎn)品貨號(hào):
      BN40553R
    • 中文名稱:
      RNA結(jié)合蛋白56抗體
    • 英文名稱:
      Rabbit anti-TAF15/RBP56 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號(hào)

      產(chǎn)品規(guī)格

      售價(jià)

      備注

    • BN40553R-100ul

      100ul

      ¥2360.00

      交叉反應(yīng):Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用:IHC-P,IHC-F,ICC,IF

    • BN40553R-200ul

      200ul

      ¥3490.00

      交叉反應(yīng):Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用:IHC-P,IHC-F,ICC,IF

    產(chǎn)品描述

    英文名稱TAF15/RBP56
    中文名稱RNA結(jié)合蛋白56抗體
    別    名68 kDa TATA-binding protein-associated factor; AF15 RNA polymerase II, TATA box binding protein (TBP) associated factor, 68 kD; Npl3; RBP56; RBP56_HUMAN; RNA binding protein 56; RNA-binding protein 56; TAF; TAF(II)68; TAF15; TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa; TAF15 RNA polymerase II, TATA box binding protein associated factor; TAF2N; TAFII68; TATA binding protein associated factor 2N; TATA-binding protein-associated factor 2N.  
    研究領(lǐng)域細(xì)胞生物  轉(zhuǎn)錄調(diào)節(jié)因子  結(jié)合蛋白  表觀遺傳學(xué)  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Rabbit, Sheep, )
    產(chǎn)品應(yīng)用IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量62kDa
    細(xì)胞定位細(xì)胞核 細(xì)胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human TAF15/RBP56:81-180/592 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

    Function:
    RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).

    Subcellular Location:
    Nucleus. Cytoplasm. Shuttles from the nucleus to the cytoplasm.

    Tissue Specificity:
    Ubiquitous. Observed in all fetal and adult tissues.

    Post-translational modifications:
    Dimethylated by PRMT1 at Arg-206 to asymmetric dimethylarginine. The methylation may favor nuclear localization and positive regulation of TAF15 transcriptional activity.
    Phosphorylated upon DNA damage, probably by ATM or ATR.

    DISEASE:
    Note=A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with NR4A3.

    Similarity:
    Belongs to the RRM TET family.
    Contains 1 RanBP2-type zinc finger.
    Contains 1 RRM (RNA recognition motif) domain.

    SWISS:
    Q92804

    Gene ID:
    8148

    Database links:

    Entrez Gene: 8148 Human

    Entrez Gene: 70439 Mouse

    Entrez Gene: 287571 Rat

    Omim: 601574 Human

    SwissProt: Q92804 Human

    Unigene: 402752 Human

    Unigene: 181050 Mouse

    Unigene: 72554 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
















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