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    磷酸化G蛋白偶合受體激酶2抗體
    • 產品貨號:
      BN40479R
    • 中文名稱:
      磷酸化G蛋白偶合受體激酶2抗體
    • 英文名稱:
      Rabbit anti-phospho-GRK2 (Ser670) Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

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    • BN40479R-100ul

      100ul

      ¥2470.00

      交叉反應:Human,Mouse(predicted:Rat,Dog,Pig,Cow,Horse,Rabbit) 推薦應用:IHC-F,IF,ELISA

    產品描述

    英文名稱phospho-GRK2 (Ser670)
    中文名稱磷酸化G蛋白偶合受體激酶2抗體
    別    名GRK2 (phospho S670); p-GRK2 (phospho S670); G-protein coupled receptor kinase 2; ADRBK 1; ADRBK1; Adrenergic beta receptor kinase 1; BARK 1; BARK; BARK1; Beta adrenergic receptor kinase 1; Beta ARK 1; Beta ARK1; G Protein Coupled Receptor Kinase 2; G protein dependent receptor kinase 2; FLJ16718; GRK 2; ARBK1_HUMAN.  
    產品類型磷酸化抗體 
    研究領域細胞生物  神經生物學  信號轉導  激酶和磷酸酶  G蛋白偶聯受體  G蛋白信號  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, )
    產品應用ELISA=1:5000-10000 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量76kDa
    細胞定位細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthesised phosphopeptide derived from human GRK2 around the phosphorylation site of Ser670:PR(p-S)PV 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq].

    Function:
    Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.

    Subunit:
    Interacts with GIT1 (By similarity). Interacts with, and phosphorylates chemokine-stimulated CCR5. Interacts with ARRB1. Interacts with LPAR1 and LPAR2. Interacts with RALA in response to LPAR1 activation. ADRBK1 and RALA mutually inhibit each other's binding to LPAR1.

    Tissue Specificity:
    Expressed in peripheral blood leukocytes.

    Similarity:
    Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 PH domain.
    Contains 1 protein kinase domain.
    Contains 1 RGS domain.

    SWISS:
    P25098

    Gene ID:
    156

    Database links:

    Entrez Gene: 156 Human

    Entrez Gene: 25238 Rat

    Omim: 109635 Human

    SwissProt: P25098 Human

    SwissProt: Q99MK8 Mouse

    SwissProt: P26817 Rat

    Unigene: 83636 Human

    Unigene: 254144 Mouse

    Unigene: 13010 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.















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