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    首頁>>免疫學>>一抗>>2'-5'-寡腺苷酸合成酶2抗體
    2'-5'-寡腺苷酸合成酶2抗體
    • 產品貨號:
      BN40467R
    • 中文名稱:
      2'-5'-寡腺苷酸合成酶2抗體
    • 英文名稱:
      Rabbit anti-OAS2 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN40467R-100ul

      100ul

      ¥2360.00

      交叉反應:Mouse(predicted:Human,Dog,Pig) 推薦應用:IHC-P,IHC-F,ICC,IF,ELISA

    • BN40467R-200ul

      200ul

      ¥3490.00

      交叉反應:Mouse(predicted:Human,Dog,Pig) 推薦應用:IHC-P,IHC-F,ICC,IF,ELISA

    產品描述

    英文名稱OAS2
    中文名稱2'-5'-寡腺苷酸合成酶2抗體
    別    名(2-5'')oligo(A) synthase 2; (2-5')oligo(A) synthetase 2; 2''-5''-oligoadenylate synthase 2; 2'-5'-oligoadenylate synthetase 2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa; 2-5A synthase 2; 2-5A synthetase 2; MGC78578; OAS2; OAS2_HUMAN; p69 OAS / p71 OAS; p69OAS / p71OAS.   
    研究領域細胞生物  免疫學  染色質和核信號  線粒體  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Mouse,  (predicted: Human, Dog, Pig, )
    產品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量82kDa
    細胞定位細胞核 細胞漿 線粒體
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human OAS2:401-500/719 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].

    Function:
    Interferon-induced, dsRNA-activated antiviral enzymewhich plays a critical role in cellular innate antiviral response.In addition, it may also play a role in other cellular processessuch as apoptosis, cell growth, differentiation and generegulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates(2-5A) from ATP which then bind to the inactive monomeric form ofribonuclease L (RNase L) leading to its dimerization and subsequentactivation. Activation of RNase L leads to degradation of cellularas well as viral RNA, resulting in the inhibition of proteinsynthesis, thus terminating viral replication. Can mediate theantiviral effect via the classical RNase L-dependent pathway or analternative antiviral pathway independent of RNase L.[CATALYTIC ACTIVITY] 3 ATP = pppA2'p5'A2'p5'A + 2 diphosphate.

    Subunit:
    Homodimer.

    Subcellular Location:
    Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum.Note=Associated with different subcellular fractions such asmitochondrial, nuclear, and rough/smooth microsomal fractions.

    Post-translational modifications:
    Myristoylation is not essential for its activity.
    Glycosylated. Glycosylation is essential for its activity.

    Similarity:
    Belongs to the 2-5A synthase family.

    SWISS:
    P29728

    Gene ID:
    4939

    Database links:

    Entrez Gene: 4939 Human

    Entrez Gene: 246728 Mouse

    Omim: 603350 Human

    SwissProt: P29728 Human

    SwissProt: E9Q9A9 Mouse

    Unigene: 414332 Human

    Unigene: 260926 Mouse



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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