最近搜索:細胞培養 微生物學 分子生物 生物化學
    首頁>>免疫學>>一抗>>SLAP蛋白抗體
    SLAP蛋白抗體
    • 產品貨號:
      BN40434R
    • 中文名稱:
      SLAP蛋白抗體
    • 英文名稱:
      Rabbit anti-SLAP Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN40434R-100ul

      100ul

      ¥2360.00

      交叉反應:Mouse(predicted:Human,Rat,Pig,Cow,Horse,Rabbit,Sheep) 推薦應用:WB,IHC-P,IHC-F,ICC,IF,ELISA

    • BN40434R-200ul

      200ul

      ¥3490.00

      交叉反應:Mouse(predicted:Human,Rat,Pig,Cow,Horse,Rabbit,Sheep) 推薦應用:WB,IHC-P,IHC-F,ICC,IF,ELISA

    產品描述

    英文名稱SLAP
    中文名稱SLAP蛋白抗體
    別    名hSLAP; SLA 1; SLA; SLA1; SLAP 1; SLAP; SLAP-1; SLAP1; SLAP1_HUMAN; Src like adapter; Src like adapter protein 1; Src like adaptor; SRC-like-adapter; Src-like-adapter protein 1.  
    研究領域細胞生物  信號轉導  激酶和磷酸酶  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Mouse,  (predicted: Human, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量31kDa
    細胞定位細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human SLAP:21-120/276 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹The Src homology 3 (SH3) region is a small protein domain of approximately 60 amino acids present in a large group of proteins. In general, it exists in association with catalytic domains, as in the nonreceptor protein-tyrosine kinases and phospholipase C-? within structural proteins, such as spectrin or Myosin; and in small adapter proteins, such as Crk and GRB2. SH3 domains are often accompanied by SH2 domains of 100 amino acids, which bind to tyrosine-phosphorylated regions of target proteins, frequently linking activated growth factors to putative signal transduction proteins. The functions of SH3 domains are not as well defined. Deletion or mutation of SH3 domains generally activate the transforming potential of nonreceptor tyrosine kinases, suggesting that SH3 mediates negative regulation of an intrinsic transforming activity. 3BP1 has been identified as a protein with a high affinity proline-rich binding site for the SH3 domain of c-Abl p120. A similar putative adapter protein, designated Slap, for Src-like adapter protein, has been cloned. Slap contains a single SH2 and SH3 domain that exhibits homology with those from members of the Src kinase family. The N- and C-termini, however, are unique.

    Function:
    Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.

    Subunit:
    Interacts with EPHA2, VAV1, LCP2 and PDGFRB (By similarity). Homodimer. Homodimerization and interaction with phosphorylated CBL occurs via its C-terminal domain. Interacts with phosphorylated proteins ZAP70, CD3Z, SYK and LAT via its SH2 domain.

    Subcellular Location:
    Cytoplasm. Endosome. Colocalizes with endosomes.

    Tissue Specificity:
    Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas.

    Similarity:
    Contains 1 SH2 domain.
    Contains 1 SH3 domain.

    SWISS:
    Q13239

    Gene ID:
    6503

    Database links:

    Entrez Gene: 6503 Human

    Entrez Gene: 20491 Mouse

    Entrez Gene: 338477 Rat

    Omim: 601099 Human

    SwissProt: Q13239 Human

    SwissProt: Q60898 Mouse

    SwissProt: P59622 Rat

    Unigene: 75367 Human



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


















    image.png

    亚洲三级在线播放| 99ri精品国产亚洲| 亚洲国产综合精品| 亚洲福利在线观看| 亚洲不卡中文字幕无码| 亚洲欧洲国产精品香蕉网| 亚洲美女高清一区二区三区| 亚洲Aⅴ在线无码播放毛片一线天| 亚洲乱码在线观看| 亚洲卡一卡二卡乱码新区| 色婷五月综激情亚洲综合| 亚洲w码欧洲s码免费| 激情内射亚洲一区二区三区爱妻| 亚洲国产成人va在线观看网址| 亚洲精品中文字幕无乱码| 亚洲成a人片在线观| 亚洲中文字幕在线无码一区二区| 亚洲人6666成人观看| 激情综合亚洲色婷婷五月| 亚洲砖码砖专无区2023| 亚洲AV无码成人网站在线观看 | 亚洲精品国产精品乱码视色 | 亚洲一区二区三区精品视频| 亚洲国产成人精品无码区在线秒播| 亚洲女人18毛片水真多| 亚洲一区精彩视频| 亚洲av永久中文无码精品| 国产精品亚洲一区二区无码| 亚洲国产成人久久精品99 | 亚洲精品网站在线观看你懂的| 亚洲第一精品电影网| 亚洲影视自拍揄拍愉拍| 亚洲国产午夜精品理论片在线播放| 久久精品国产亚洲av品善| 亚洲日韩国产一区二区三区| 亚洲午夜久久久影院| 亚洲另类激情综合偷自拍| 亚洲人成网站在线观看播放动漫 | 国产v亚洲v天堂a无| 精品韩国亚洲av无码不卡区| 亚洲人成无码久久电影网站|