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    首頁>>免疫學>>一抗>>鈣調神經磷酸酶調節蛋白3抗體(唐氏綜合征候選區域蛋白1樣蛋白3)
    鈣調神經磷酸酶調節蛋白3抗體(唐氏綜合征候選區域蛋白1樣蛋白3)
    • 產品貨號:
      BN40310R
    • 中文名稱:
      鈣調神經磷酸酶調節蛋白3抗體(唐氏綜合征候選區域蛋白1樣蛋白3)
    • 英文名稱:
      Rabbit anti-Calcipressin 3 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN40310R-100ul

      100ul

      ¥2360.00

      交叉反應:Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Rabbit,Sheep) 推薦應用:WB,IHC-P,IHC-F,ICC,IF,ELISA

    • BN40310R-200ul

      200ul

      ¥3490.00

      交叉反應:Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Rabbit,Sheep) 推薦應用:WB,IHC-P,IHC-F,ICC,IF,ELISA

    產品描述

    英文名稱Calcipressin 3
    中文名稱鈣調神經磷酸酶調節蛋白3抗體(唐氏綜合征候選區域蛋白1樣蛋白3)
    別    名Calcipressin-3; Down syndrome candidate region 1 like 2; regulator of calcineurin 3; Down syndrome candidate region 1 like protein 2; Down syndrome candidate region 1-like protein 2; Down syndrome critical region gene 1 like 2; DSCR1L2; hRCN3; MCIP3; Myocyte enriched calcineurin interacting protein 3; Myocyte-enriched calcineurin-interacting protein 3; RCAN family member 3; RCAN3; RCAN3_HUMAN; RCN3; RCN3; MCIP3; Regulator of calcineurin 3.  
    研究領域細胞生物  神經生物學  信號轉導  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量27kDa
    細胞定位細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human Calcipressin 3:151-241/241 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Calcineurin is a Ca(2+) dependent protein phosphatase that is involed in several neuornal functions. Proteins belonging to the RCAN (Regulator of calcineurin) family modulate the activity of Calcineurin through a valine-rich region within their carboxyl tail. RCANs compete with NFATs (Nuclear factor of activated T-cells) for binding to the same docking site in calcineurin, which results in either inhibition or activation of calcineurin activity. Calcipressin-2, also known as RCAN2 and DSCR1L1 (Down syndrome candidate region 1-like 1), is a 197 amino acid protein that is highly expressed in both the cytoplasm and nucleus of neurons and is the only RCAN family member that is found in glial cells. Calcipressin-3, also known as RCAN3 and DSCR1L2 (Down syndrome candidate region 1-like protein 2), is a 241 amino acid protein that potentially is involved in central nervous system development. Calcipressin-3 interacts with cardiac troponin I, suggesting that it may play a role in cardiac contraction events.

    Function:
    Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

    Tissue Specificity:
    Highest expression in heart, skeletal muscle kidney, liver and peripheral blood leukocytes. Lower expression in all other tissues.

    Similarity:
    Belongs to the RCAN family.

    SWISS:
    Q9UKA8

    Gene ID:
    11123

    Database links:

    Entrez Gene: 11123 Human

    Entrez Gene: 53902 Mouse

    Omim: 605860 Human

    SwissProt: Q9UKA8 Human

    SwissProt: Q9JKK0 Mouse

    Unigene: 656799 Human

    Unigene: 331970 Mouse



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.















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