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    首頁>>免疫學>>一抗>>環指蛋白111抗體
    環指蛋白111抗體
    • 產品貨號:
      BN40272R
    • 中文名稱:
      環指蛋白111抗體
    • 英文名稱:
      Rabbit anti-RNF111 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN40272R-100ul

      100ul

      ¥2360.00

      交叉反應:Mouse,Rat(predicted:Human,Dog,Cow,Rabbit,Sheep) 推薦應用:IHC-P,IHC-F,ICC,IF,ELISA

    • BN40272R-200ul

      200ul

      ¥3490.00

      交叉反應:Mouse,Rat(predicted:Human,Dog,Cow,Rabbit,Sheep) 推薦應用:IHC-P,IHC-F,ICC,IF,ELISA

    產品描述

    英文名稱RNF111
    中文名稱環指蛋白111抗體
    別    名ARK; Arkadia; DKFZp313E0731; DKFZp686H1966; DKFZp761D081; E3 ubiquitin protein ligase Arkadia; FLJ38008; Ring finger protein 111; RNF 111; RN111_HUMAN.  
    研究領域細胞生物  免疫學  信號轉導  生長因子和激素  泛素  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Mouse, Rat,  (predicted: Human, Dog, Cow, Rabbit, Sheep, )
    產品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量109kDa
    細胞定位細胞核 細胞漿 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human RNF111:851-950/994 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

    Function:
    Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin-protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.

    Subunit:
    Interacts with SMAD6, SMAD7, AXIN1, AXIN2 and SKIL isoform SNON. Part of a complex containing RNF111, AXIN1 and SMAD7. Interacts (via SIM domains) with SUMO1 and SUMO2.

    Subcellular Location:
    Cytoplasmic and Nuclear

    Tissue Specificity:
    Broadly expressed.

    Similarity:
    Contains 1 RING-type zinc finger.

    SWISS:
    Q6ZNA4

    Gene ID:
    54778

    Database links:

    Entrez Gene: 54778 Human

    Omim: 605840 Human

    SwissProt: Q6ZNA4 Human

    Unigene: 404423 Human



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications


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